All Diablo 4 Endgame boss Unique loot tables

Amitesh Dhar
Diablo 4 Malphas

In Diablo 4, the quickest way to farm Unique items in the game is by taking on the endgame bosses. This list contains all the Uniques that every Diablo 4 endgame boss drops and will help you plan out your builds quickly.

Uniques are special items in Diablo 4 that contain affixes with the potential to increase the efficiency of your build. Although you can come across these items in the open world, you can target-farm them by defeating the endgame bosses in the game.

Introduced in Season 2, every endgame boss in Diablo 4 has a loot table which is unique to them. The loot table lists out items that you have a chance of acquiring when you’ve defeated the boss.

These endgame bosses and their loot tables are the same across the Eternal Realm and the Seasonal Realm, so none of your characters will miss out on the loot drops.

To help you target farm Uniques, here’s a list of all Diablo 4 endgame bosses and their Unique loot tables.

All Diablo 4 endgame boss loot tables

It’s worth noting that while these bosses, except Malphas, are available across both realms, you can summon and defeat them in World Tier 3: Nightmare, and World Tier 4: Torment, but they drop Uniques in World Tier 4 only.

Echo of Varshan loot table

Varshan in Diablo 4
The Echo of Varshan is a formidable foe.

How to summon: Collect different Malignant body parts (Gurgling Head, Trembling Hand, Malignant Heart, Blackened Femur.)

You can collect the parts above from the Tree of Wishpers caches. Once you’ve collected all the items, head into the Malignant Burrow below the Tree of Whispers to summon this boss. Once you defeat it, you can claim the following Unique rewards:

ClassUnique
SorcererTal Rasha’s Iridescent Loop, Staff of Endless Rage, Esu’s Heirloom, Raiment of the Infinite
DruidAiridah’s Inexorable Will, Mad Wolf’s Glee, Vasily’s Prayer, Greatstaff of the Crone
BarbarianRing of Red Furor, Fields of Crimson, 100,000 Steps, Gohr’s Devastating Grips
NecromancerRing of the Sacrilegious Soul, Bloodless Scream, Deathless Visage, Deathspeaker’s Pendant
RogueWrithing Band of Trickery, Condemnation, Eyes in the Dark, Skyhunter
All classesFrostburn, Mother’s Embrace

Grigoire, the Galvanic Saint loot table

Grigoire Diablo 4
Grigoire, the Galvanic Saint can drop certain Uniques like the Hunter’s Zenith.

How to summon: Collect Living Steel from Helltides

Once you’ve collected enough Living Steel, make your way to the Hall of the Pentinent dungeon in Dry Steppes. You’ll need two Living Steel to summon him in World Tier 3, and five Living Steel to summon him in World Tier 4 in Diablo 4. You can check out the Uniques for Grigoire in the following table:

ClassUnique
SorcererStaff of Lam Esen, Iceheart Brais, Gloves of the Illuminator
DruidInsatiable Fury, Hunter’s Zenith, Waxing Gibbous, The Butcher’s Cleaver
BarbarianRamaladni’s Magnum Opus, Rage of Harrogath, Ancients’ Oath, Battle Trance, The Butcher’s Cleaver
NecromancerBlood Artisan’s Cuirass, Howl from Below, Greaves of the Empty Tomb
RogueWord of Hakan, Grasp of Shadow, Windforce
All classesPenitent Greaves

Lord Zir loot table

Lord Zir in Diablo 4
Lord Zir is one of the most difficult bosses in Diablo 4.

How to summon: Collect Exquisite Blood from Legion Events.

Although he was the boss in the past Season of Blood, you will still be able to summon him in the game. Head to The Ancient Seat in Fractured Peaks to summon Zir, and check out the Uniques that he drops when defeated:

ClassUnique
SorcererStaff of Endless Rage, Iceheart Brais, Raiment of the Infinite, Esadora’s Overflowing Cameo
DruidMad Wolf’s Glee, Vasily’s Prayer, Greatstaff of the Crone, Fleshrender, The Butcher’s Cleaver
BarbarianRamaladni’s Magnus Opus, Rage of Harrogath, Gohr’s Devastating Grips, Overkill, The Butcher’s Cleaver
NecromancerBlood Artisan’s Cuirass, Deathless Visage, Greaves of the Empty Tomb, Lidless Wall
RogueGrasp of Shadow, Eyes in the Dark, Skyhunter, Asheara’s Khanjar
All classesPenitent Greaves, Razorplate, Temerity

The Beast in Ice loot table

Diablo 4 Season 2 Beast in Ice
Beast in Ice is an extremely formidable enemy in the game.

How to summon: Collect Distilled Fear by completing Tier 30 Nightmare Dungeons.

Once you’ve collected enough Distilled Fear, make your way to the Occultist in Diablo 4 to craft the Glacial Fissure Nightmare Sigil. Here are the Uniques that you can get by defeating The Beast in Ice boss in Diablo 4:

ClassUnique
SorcererStaff of Lam Esen, Esu’s Heirloom, Gloves of the Illuminator, The Oculus, Starfall Coronet
DruidInsatiable Fury, Hunter’s Zenith, Waxing Gibbous, Storm’s Companion, Unsung Ascetic’s Wraps
BarbarianFields of Crimson, 100,000 Steps, Ancients’ Oath, Battle Trance, Hellhammer, Ring of the Ravenous
NecromancerBloodless Scream, Howl from Below, Deathspeaker’s Pendant, Ring of Mendeln, Mutilator Plate
RogueCondemnation, Word of Hakan, Windforce, Eaglehorn, Beastfall Boots
All classesFrostburn, Mother’s Embrace, Fists of Fate, Tassets of Dawning Sky, Paingorger’s Gauntlets

Duriel, King of Maggots loot table

Echo of Duriel Diablo 4 Season 2
You can get Tibault’s Will by defeating Duriel.

How to summon: Collect Mucus-Slick Eggs and Shards of Agony by defeating Varshan and Grigoire respectively.

It’s worth remembering that the Mucus-Slick Eggs are only available in World Tier 4. So once you’ve collected the two items, you need to make your way to the Gaping Crevasse dungeon and find the altar to summon Duriel.

Duriel is the only boss in the game that drops Uber Uniques, so you should farm the fight whenever you can.

ClassUnique
SorcererFlamescar, Blue Rose
DruidTempest Roar, Dolmen Stone
BarbarianAzurewrath, Tuskhelm of Joritz the Mighty
NecromancerBlack River, Blood Moon Breeches
RogueCowl of the Nameless, Scoundrel’s Leathers
All classesGodslayer Crown, Flickerstep, Tibault’s Will, X’Fal’s Corroded Signet, Soulbrand, Banished Lord’s Talisman
Uber UniquesDoombringer (Barbarian, Necromancer, Rogue), The Grandfather (Barbarian, Necromancer), Melted Heart of Selig, Andariel’s Visage, Harlequin Crest, Ring of Starless Skies, Abavarion, Spear of Lycander (Druid, Sorcerer)

Malphas loot table

Malphas in Diablo 4
Uber Malphas can be accessed in the Seasonal Realm only

How to summon: Collect Igneous Core and Shattered Stones by completing Arcane Tremor events and defeating Construct enemies in the open world.

Of all the Endgame bosses, Malphas is the only one that can be exclusively accessed in the Seasonal Realm in Diablo 4. It’s currently unclear if he’ll be added to the Eternal Realm in Season 4 because his drops revolve around seasonal content only.

That said, Uber Malphas can be found in the Vault of the Loom and drops the two most powerful Tuning Stones in the game right now. They are as follows:

ClassUniques
All ClassesEvernight (Tuning Stone), Genesis (Tuning Stone)

For more on Diablo 4, be sure to check out the rest of our content:

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About The Author

Amitesh started writing about video games in 2020. He previously worked at Sportskeeda, Gfinity, and Attack of the Fanboy before joining CharlieIntel in 2024. He's an avid fan of Destiny 2 and Diablo 4 and an expert on all things Fortnite. You can get in touch with him at [email protected].